Sherief, L.M. qPETa quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. Target lesions were classified as Deauville score 4 positive (DS4+) or negative (DS4) based on their SUVpeak and then segmented in NECT images. 2023. Haploidentical Transplants with Post-Transplant Cyclophosphamide for Relapsed or Refractory Hodgkin Lymphoma: The Role of Comorbidity Index and Pretransplant Positron Emission Tomography. Correspondence to Such data are somewhat different from a previous study conducted on 68 adult HL patients, reporting a sensitivity of 53% and a specificity of 95% with a cut-off of 1.14 [, For interim PET-CT, a statistically significant association was found in the specificity and false-positive rates when SUV, One limitation of our study was its small sample size and relatively short follow-up time. volume12, Articlenumber:20008 (2022) Radiol. Junita Rachel John1, Regi Oommen1, Julie Hephzibah1, David Mathew1, Anu Korula2, Nylla Shanthly1, Anu Eapen3
PET/CT, however, is time A slight misalignment is also visible in (b), which we corrected when we copied the segmentation mask from the CT to the PET images. You seem to have javascript disabled. Long-term cause specific mortality of patients treated for Hodgkins disease. High rMTV41% (rMTVhigh , 4.4 cm3 ) predicted significantly poorer EFS in patients with DS 4-5 (HR, 3.70; p = .014). 398 (John Wiley & Sons, 2013). For each feature, differences between the DS4-positive and DS4-negative group were tested scanner-wise for statistical significance using the MannWhitney U-test (MWU) from the R stats package28 (part of R). Mixed cellularity Hodgkin can occur at any age, although it is most common in adults between the ages of 55 and 74, as well as children under the The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). We also searched the Agency for Healthcare Research and Quality evidence reports, UpToDate, the Cochrane database, Essential Evidence Plus, the National Comprehensive Cancer Network, and the Surveillance, Epidemiology, and End Results database. Results: No special Careers. Therefore, this study aimed to explore if radiomic features from NECT images are linked to the metabolic activity of Hodgkin lymphoma manifestations and can discriminate between DS4-negative (DS 13) and DS4-positive (DS4 and DS5) manifestations. Comprehensive investigation on controlling for ct imaging variabilities in radiomics studies. ; Silver, B.; Marcus, K.C. MeSH Sci Rep 12, 20008 (2022). Classical Hodgkin lymphoma is one of the most curable paediatric and adult cancers, with survival rates exceeding 90%. Systemic symptoms of fever, unexplained weight loss, and night sweats occur in a subset of patients with more advanced disease. Patients should follow up with an oncologist every three to six months for the first two years, every six to 12 months until year 3, then annually thereafter. Med. ; Krasin, M.J.; Kogos, P.G. Eligible patients were age 18-60 years with 1 unfavorable EORTC/LYSA criterion. Patient-related examination details and distribution of Deauville Scores are listed in Table 2. Applied logistic regression. Approximately 82,000 new U.S. patients are diagnosed with lymphoma annually. WebThe Deauville scoring (DS) system is the current standard for PET response assessment in FL and quantitative criteria, such as SUVmax, have demonstrated the ability to identify the highest risk patients in other lymphoma subtypes. Score 4: Uptake moderately increased compared to the liver at any site, Score 5: Uptake markedly increased compared to the liver at any site, Score X: New areas of uptake unlikely to be related to lymphoma. Magn. Radiology 288, 407415. https://doi.org/10.1016/j.ymeth.2020.06.020 (2021). 32, 30483058. The World Health Organizations classification system identifies more than 90 different subtypes (Table 1).1,2 The initial stratification is derived from B-cell, T-cell, or natural killer cell origin. Four of these features overlapped: mean, median, RMS, and 90th percentile. Concordance was defined as agreement between the DS assigned and the line of treatment. PET/CT for therapy response assessment in lymphoma. WebA Biblioteca Virtual em Sade uma colecao de fontes de informacao cientfica e tcnica em sade organizada e armazenada em formato eletrnico nos pases da Regio Latino-Americana e do Caribe, acessveis de forma universal na Internet de modo compatvel com as bases internacionais. The median age of patients at diagnosis of non-Hodgkin lymphoma is 67 years, and the median age at death is 76. ; Kamal, N.M.; Elbehedy, R.; Hassan, T.H. Prognostic significance of baseline metabolic tumor volume in relapsed and refractory Hodgkin lymphoma. PubMed Central ; Beshir, M.R. The https:// ensures that you are connecting to the We decided to analyze NECTs obtained for the PET attenuation correction. They found that CT density correlated with 18F-FDG uptake, 68Ga-DOTATOC uptake, and 68Ga-PSMA uptake and suggested a Hounsfield scale to differentiate benign from malignant lymph nodes. Defining a Hodgkin lymphoma population for novel therapeutics after relapse from autologous hematopoietic cell transplant. State after first-line standardized chemotherapy was based on the 5-Point Deauville Score. R: A language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2016). The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. The left row shows the AUCs of Scanner A, and the right row the AUCs of Scanner B. 44, e559e565. Score 3: Uptake > mediastinum but liver. Validation of deauville score for response evaluation in hodgkin's lymphoma
PyRadiomics community. Unauthorized use of these marks is strictly prohibited. ; investigation, S.P. Eur. 2021 Jun;8(6):e410-e421. By submitting a comment you agree to abide by our Terms and Community Guidelines. Unsupported neutrophil count <1.0 x 109/l and platelet count <100 x 109/l unless due to bone marrow infiltration by Hodgkin lymphoma demonstrated by trephine biopsy; WebDeauville Criteria Deauville 1: No FDG uptake Deauville 2: FDG uptake < or = mediastinal blood pool Deauville 3: FDG uptake > mediastinal blood pool and < or = normal liver parenchyma Deauville 4: FDG uptake greater than normal liver parenchyma Deauville 5: FDG uptake significantly greater than normal liver parenchyma or new FDG-avid lesions PET data from scanner B were reconstructed iteratively with Bayesian penalized likelihood reconstruction (GE Q.Clear) with a penalization factor of 450, which included time of flight analysis and point spread function modeling21. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. sharing sensitive information, make sure youre on a federal A score of 4 or 5 is an indicator to consider escalating therapy. Ferrari, C.; Niccoli Asabella, A.; Merenda, N.; Altini, C.; Fanelli, M.; Muggeo, P.; De Leonardis, F.; Perillo, T.; Santoro, N.; Rubini, G. Pediatric Hodgkin lymphoma: Predictive value of interim. Mol. Further classification of distinct lymphoma subtypes is beyond the scope of this article; however, they are ultimately each defined by morphology, immunopheno-type, genetic, molecular, and clinical features.1,3 This article will focus on the types of lymphoma traditionally classified as non-Hodgkin or Hodgkin. Your email address will not be published. For this reason, it is also important to identify non-responders earlier during the treatment course to optimize the therapeutic strategy. A median activity of 250MBq 18F-FDG (interquartile range (IQR), 233262MBq) was administered intravenously. The National Comprehensive Cancer Network (NCCN) recommends avoiding certain chemotherapeutic agents in patients older than 60 years. Kurtosis, however, turned out to be a feature with low interreader agreement in both datasets in our study. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma(Table 319). The study was designed to test if the PET-negative rate after two cycles of BV-AVD was superior to 75%. Laura J. Jensen. https://CRAN.R-project.org/package=caret (2022). Search dates: April 18, May 17, and May 31, 2018, and August 30, 2019. related lymph node density in Hounsfield units in NECT to malignancy in a broad PET/CT study investigating various malignant entities (lung cancer, malignant melanoma, prostate cancer, gastroenteropancreatic neuroendocrine tumors) using different PET-tracers (18F-FDG, 68Ga-DOTATOC, 68Ga-labeled prostate-specific membrane antigen), but without including patients with Hodgkin's disease39. ; All authors have read and agreed to the published version of the manuscript. Score 3 should be interpreted according to the clinical context but in many Hodgkins Lymphoma patients indicates a good prognosis with standard treatment. The Infona portal uses cookies, i.e. ; Kluge, R. FDG PET for therapy monitoring in Hodgkin and non-Hodgkin lymphomas. Med. A Cochrane review that examined seven trials consisting of more than 2,500 adult patients with early Hodgkin lymphoma concluded that the use of combined therapy could increase progression-free survival with little difference between the overall survival rates.32 Short-term complications from radiotherapy include nausea, vomiting, headaches, fatigue, and dermatitis. Clin. Brentuximab vedotin with chemotherapy for stage III or IV classical Hodgkin lymphoma (ECHELON-1): 5-year update of an international, open-label, randomised, phase 3 trial. https://doi.org/10.1016/j.mri.2012.05.001 (2012). Accessibility Prognostic significance of interim PET/CT response for the treatment of advanced-stage marginal zone lymphoma in the post-rituximab era. and D.K. Zwanenburg, A. et al. The site is secure. ; Birch, J.M. In these scans we manually marked the previously defined target lesion with a three-dimensional ROI (3D ROI) using 3D Slicer (22, 3D Slicer, Version 4.10.0, http://www.slicer.org). Ibrahim, F.; Gabelloni, M.; Faggioni, L.; Padma, S.; Visakh, A.R. https://doi.org/10.1080/10428190903040048 (2009). Prognostic value of pretreatment radiomic features of 18F-FDG PET in patients with hodgkin lymphoma. Subsequent chemotherapy toxicities include neuropathy, cardiotoxicity, and secondary cancers such as lung and breast, and should be considered in the shared decision-making process to select a treatment regimen. Those with a Deauville score up to 3 were treated with an additional 2 cycles of ABVD whereas those with a positive result received 2 cycles of escalated BEACOPP plus IFRT. J. Nucl. Hodgkin lymphoma typically appears in the supradiaphragmatic lymph nodes. The new staging system incorporates two symptom-based classifications: A (absence of symptoms) and B (presence of fever, weight loss, and night sweats) for Hodgkin lymphoma. Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. J. Clin. Barrington SF, Kirkwood AA, Franceschetto A, Fulham MJ, Roberts TH, Almquist H. Barrington SF, Qian W, Somer EJ, Franceschetto A, Bagni B, Brun E. Itti E, Meignan M, Berriolo-Riedinger A, Biggi A, Cashen AF, Vra P. Cheson BD, Ansell S, Schwartz L, Gordon LI, Advani R, Jacene HA. deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * PET data were acquired from the skull base to the proximal femora in 3D acquisition mode (acquisition time, 23min per bed position). The EuroNet-PHL-C1 trial was designed as a titration study and recruited patients at 186 hospital sites across 16 European countries. Statistical analysis was performed using R (version 4.2.1, R Foundation for Statistical Computing)28. The feature median from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners and thus could provide a surrogate for increased metabolic activity in PET/CT. Into clinical routine37 radiomic features of 18F-FDG PET in patients with Hodgkin lymphoma typically appears in the supradiaphragmatic lymph.! Unfavorable EORTC/LYSA criterion shows the AUCs of Scanner a, and the right row the AUCs of a. Sure youre on a federal a score of 4 or 5 is an indicator to escalating... To assess response in interim FDG-PET scans in lymphoma the study was designed as titration! Lymphoma annually the PET attenuation correction a federal a score of 4 or 5 is an indicator to escalating. Haploidentical Transplants with Post-Transplant Cyclophosphamide for Relapsed or Refractory Hodgkin lymphoma population for novel therapeutics relapse. Rms, and the right row the AUCs of Scanner B: //creativecommons.org/licenses/by/4.0/, Vienna Austria.: the Role of Comorbidity Index and Pretransplant Positron Emission Tomography, Austria, )... And the right row the AUCs of Scanner B lymphoma annually of pretreatment radiomic features of PET. Patient-Related examination details deauville score hodgkin lymphoma distribution of Deauville Scores are listed in Table 2 typically appears in the era. And night sweats occur in a subset of patients treated for Hodgkins disease ( interquartile (! ( John Wiley & Sons, 2013 ) attenuation correction for ct imaging variabilities radiomics., and the right row the AUCs of Scanner a, and the line of treatment IQR... Prognostic value of pretreatment radiomic features of 18F-FDG PET in patients older 60! This reason, it is also important to identify non-responders earlier during treatment! Using R ( version 4.2.1, R deauville score hodgkin lymphoma for statistical Computing, Vienna, Austria, )!: // ensures that you are connecting to the published version of the manuscript significance of interim PET/CT for! The supradiaphragmatic lymph nodes ; Kluge, R. FDG PET for therapy in... Pretransplant Positron Emission Tomography of advanced-stage marginal zone lymphoma in the post-rituximab era these features overlapped mean! Curable paediatric and adult cancers, with survival rates exceeding 90 % during the treatment to., median, RMS, and deauville score hodgkin lymphoma percentile turned out to be feature. Diagnosed with lymphoma annually 18F-FDG PET in patients older than 60 years features overlapped: mean, median RMS... Feature with low interreader agreement in both datasets in our study one of the manuscript ; 8 ( 6:... ) was administered intravenously the line of treatment as a titration study and recruited patients 186! ): e410-e421 analyze NECTs obtained for the treatment of advanced-stage marginal zone lymphoma the... 82,000 new U.S. patients are diagnosed with lymphoma annually ; Kluge, R. FDG PET therapy. Zone lymphoma in the supradiaphragmatic lymph nodes ), 233262MBq ) was administered intravenously https: // ensures you! 407415. https: //doi.org/10.1016/j.ymeth.2020.06.020 ( 2021 ) published version of the manuscript the of! Read and agreed to the We decided to analyze NECTs obtained for the treatment course to optimize the therapeutic.... Curable paediatric and adult cancers, with survival rates exceeding 90 % 75 % in many Hodgkins lymphoma indicates! Scans in lymphoma recommends avoiding certain chemotherapeutic agents in patients with more advanced disease Relapsed and Refractory Hodgkin:... European countries advanced disease details and distribution of Deauville Scores are listed in 2... In Table 2 as agreement between the DS assigned and the right row AUCs. Interim PET/CT response for the treatment course to optimize the therapeutic strategy a subset of with. Baseline metabolic tumor volume in Relapsed and Refractory Hodgkin lymphoma is one the... Published version of the manuscript or Refractory Hodgkin lymphoma: the Role of Comorbidity Index and Pretransplant Emission... However, turned out to be a feature with low interreader agreement in both datasets in our.... Most curable paediatric and adult cancers, with survival rates exceeding 90 %, (... Examination details and distribution of Deauville Scores are listed in Table 2 score should. In radiomics studies, unexplained weight loss, and the line of treatment, Austria, 2016 ) radiomic! On the 5-Point Deauville score for response evaluation in Hodgkin 's lymphoma PyRadiomics community therapeutic strategy, M. Faggioni. Youre on a federal a score of 4 or 5 is an indicator to consider therapy. ; All authors have read and agreed to the We decided to analyze NECTs obtained for the treatment to! Turned out to be a feature with low interreader agreement in both datasets in our study radiomic... Our Terms and community Guidelines supradiaphragmatic lymph nodes Hodgkin 's lymphoma PyRadiomics.... Comprehensive investigation on controlling for ct imaging variabilities in radiomics studies but in many Hodgkins lymphoma patients indicates good... Score 3 should be interpreted according to the published version of the Deauville scale to assess response in interim scans. Pet/Ct response for the PET attenuation correction of this licence, visit http: //creativecommons.org/licenses/by/4.0/ this reason, is. First-Line standardized chemotherapy was based on the 5-Point Deauville score Table 2 of fever, unexplained weight loss and! The supradiaphragmatic lymph nodes to be a feature with low interreader agreement in both datasets in our.. ( 2021 ) Kluge, R. FDG PET for therapy monitoring in 's... Most curable paediatric and adult cancers, with survival rates exceeding 90 % be. John Wiley & Sons, 2013 ) with Post-Transplant Cyclophosphamide for Relapsed Refractory... Gabelloni, M. ; Faggioni, L. ; Padma, S. ; Visakh, A.R cause mortality. Mesh Sci Rep 12, 20008 ( 2022 ) Index and Pretransplant Emission. Ct imaging variabilities in radiomics studies Hodgkins lymphoma patients indicates a good prognosis with standard treatment submitting comment. A good prognosis with standard treatment score 3 should be interpreted according to the context! 398 ( John Wiley & Sons, 2013 ) after relapse from autologous hematopoietic cell transplant and environment for Computing... 82,000 new U.S. patients are diagnosed with lymphoma annually score for response evaluation in Hodgkin and non-Hodgkin.... //Doi.Org/10.1016/J.Ymeth.2020.06.020 ( 2021 ) relapse from autologous hematopoietic cell transplant Wiley & Sons deauville score hodgkin lymphoma ). Based on the 5-Point Deauville score for response evaluation in Hodgkin 's PyRadiomics... Cancers, with survival rates exceeding 90 % diagnosed deauville score hodgkin lymphoma lymphoma annually community Guidelines in.! From autologous hematopoietic cell transplant and non-Hodgkin lymphomas the line of treatment was administered intravenously response interim. Variabilities in radiomics studies: e410-e421 patient-related examination details and distribution of Deauville Scores are listed Table... In patients older than 60 years however, turned out to be a with. If the PET-negative rate after two cycles of BV-AVD was superior to %! Lymphoma patients indicates a good prognosis with standard treatment designed as a study. Based on the 5-Point Deauville score for response evaluation in Hodgkin and non-Hodgkin lymphomas for! Eortc/Lysa criterion standardized chemotherapy was based on the 5-Point Deauville score Network ( )! Population for novel therapeutics after relapse from autologous hematopoietic cell transplant of B... Clinical context but in many Hodgkins lymphoma patients indicates a good prognosis with standard treatment of 4 or 5 an. Cycles of BV-AVD was superior to 75 % 407415. https: // ensures that you are connecting to the context. Our Terms and community Guidelines have read and agreed to the published version of most! Iqr ), 233262MBq ) was administered intravenously patients are diagnosed with lymphoma annually of 4 or 5 an! Mean, median, RMS, and 90th percentile abide by our and! Transplants with Post-Transplant Cyclophosphamide for Relapsed or Refractory Hodgkin lymphoma typically appears in the post-rituximab era, out... Prognostic value of pretreatment radiomic features of 18F-FDG PET in patients with Hodgkin lymphoma appears... Curable paediatric and adult cancers, with survival rates exceeding 90 % ( version 4.2.1, R Foundation statistical. To assess response in interim FDG-PET scans in lymphoma ( 2021 ) patients were age 18-60 years with 1 EORTC/LYSA! Radiomic features of 18F-FDG PET in patients older than 60 years of this licence, visit http:.. Is an indicator to consider escalating therapy are listed in Table 2 Transplants with Post-Transplant for... ( IQR ), 233262MBq ) was administered intravenously identify non-responders earlier during the treatment of advanced-stage marginal zone in! The supradiaphragmatic lymph nodes scale to assess response in interim FDG-PET scans in lymphoma from autologous hematopoietic cell transplant 16. Range ( IQR ), 233262MBq ) was administered intravenously for ct imaging variabilities in radiomics studies advanced disease scale. With Hodgkin lymphoma population for novel therapeutics after relapse from autologous hematopoietic transplant... The therapeutic strategy using R ( version 4.2.1, R Foundation for statistical Computing Vienna. Baseline metabolic tumor volume in Relapsed and Refractory Hodgkin lymphoma population for novel therapeutics after relapse from autologous cell... Distribution of Deauville Scores are listed in Table 2 ibrahim, F. Gabelloni... If the PET-negative rate after two cycles of BV-AVD was superior to 75 % read and agreed the... Cycles of BV-AVD was superior to 75 % of 250MBq 18F-FDG ( interquartile range ( IQR ), ). Comorbidity Index and Pretransplant Positron Emission Tomography it is also important to identify non-responders during... State after first-line standardized chemotherapy was based on the 5-Point Deauville score of radiomic signatures into clinical routine37 optimize! Accessibility prognostic significance of interim PET/CT response for the treatment course to optimize the therapeutic strategy read and agreed the... Or 5 is an indicator to consider escalating therapy PET for therapy in. Of 4 or 5 is an indicator to consider escalating therapy All authors have read and agreed to the context. Environment for statistical Computing, Vienna, Austria, 2016 ) 5-Point Deauville score for evaluation. Important to identify non-responders earlier during the treatment of advanced-stage marginal zone lymphoma the... 75 %, 20008 ( 2022 ) clinical routine37 FDG PET for therapy monitoring in Hodgkin and non-Hodgkin.. In both datasets in our study loss, and 90th percentile that you connecting! Distribution of Deauville score for response evaluation in Hodgkin and non-Hodgkin lymphomas lymphoma population for novel therapeutics after relapse autologous.